Endocrine Abstracts

The androgen receptor (AR) is the key transcription factor mediating androgen action during embryogenesis and postnatal life. Both adrenal and gonadal androgens act through the AR, which therefore has a major role both in female and male sexual maturation. Mutations in the X-chromosomally localized AR-gene have been associated with a variety of human disorders, namely in-born errors of male sexual differentiation as well as malignancy of endocrine organs such as prostate cance...